Most methods of plant transformation and editing procedures are reliant on older “transformation competent” germplasm and are prone to tissue culture-induced mutations, creating unknown variables in the plant, complicating phenotypic selection. Increased yield, nitrogen utilization, disease resistance, insect resistance, drought and heat tolerance, and nutritional improvement are just a few of the traits that are targets of these genome modifying techniques. Plant genetic transformation and gene editing are critically important methods for the field of agronomic research as well as advancing new traits of agronomic importance. REFERENCE TO A SEQUENCE LISTING SUBMITTED VIA EFS-WEB STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH 19, 2019, which is incorporated herein by reference in its entirety. Losing that few dozens of mana by letting monsters into your wiztower at the beginning of the battle can be fatal in the long run.This application claims priority to U.S. If monsters can reach your wiztower in the early waves, you are either doing something wrong (wrong tower placement, started multiple waves early without proper defenses), have a wrong skill configuration, or don't have a level high enough to have a chance on that stage.Be careful with the gem bombing mode - If you click too much on a wave stone and run out af ammo, you can accidentally start the wave early with your "extra" click.Gem transmute shrines help getting shrine burst amulets.
When fighting a guardian, finish the minions first to severely reduce the armor of the guardian. replace gems, build some "emergency" towers, throw your gems). If things go grim, switch the game speed back to normal, so you have more time to react (e.g. This limits the times you can anger a wave, but with an armor reduce shrine, you can tear of some of their armor so you can summon more and go for a higher score and XP. The risky thing in summoning more monsters is that every time you drop a gem on a wave stone, the armor level of the monsters in that wave will get higher, and they can easily become bulletproof against your towers. Poison gems, when placed in traps, are great for weakening each monster, especially the first few waves. It can make all the difference in the long run. Use mana (orange) gems in traps at the exit of the main monster base the more traps the better. Level up by going back to an early stage and summoning more monsters - this way you can reach a much higher XP for that stage/mode. Look out especially for highlighted modes which give 3x XP. Level up by going back and beating previous levels in new battle modes - the XP you gain in each mode adds up. Different stages and battle modes may require very different skill configurations. if you can't beat a stage and tried multiple times:. Use your mana to build up your defenses first. Don't destroy a beacon unless necessary, especially at the beginning of the battle. If you destroy a minor monster base, the monsters that would come out of it will be "redirected" to the main monster base. Monsters take more and more mana each time they reach your wizard towwer, so be careful with hordes of fast monsters. You can leech more mana from the slowed monster or have a greater chance of shocking/piercing it. Place a trap right next to an other one, place a slowing gem in the first trap and a mana gain/armor reduce/shocking gem in the second one. Place a trap near a group of towers and place a slowing gem in it, this way the monsters will have to crawl by the towers for a longer time, taking more shots. It's usually better to have more towers with somewhat weaker gems in them, than a few towers with stronger gems. Look at the range indicator (yellow circle) of the inserted gem to see how far it can shoot, and place it in a tower that can give it the longest path cover. Place your towers in positions where they can cover the longest path possible. It will have all 8 abilities (in a very small portion each though) and some bonuses to its basic values. 
If you have all 8 gem types available, you can create a prismatic gem. Try to avoid making gems containing more than two base colors. If you combine two gems of different types, you get both specials but with a decreased power. Pure gems have the strongest special abilities. This can further be improved with the Dual gem mastery skill. 
Dual gems are superior to pure gems, they get larger bonuses to their damage, range, and firing speed.
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